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deep sequencing and microarray core facility  (Johns Hopkins HealthCare)

 
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    Johns Hopkins HealthCare deep sequencing and microarray core facility
    Deep Sequencing And Microarray Core Facility, supplied by Johns Hopkins HealthCare, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/deep+sequencing+microarray/deep+sequencing+and+microarray+core/pm39341835-495-13-6
    Average 90 stars, based on 1 article reviews
    deep sequencing and microarray core facility - by Bioz Stars, 2026-10
    90/100 stars

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    Related Articles

    Isolation:

    Article Title: Altered keratinocyte differentiation is an early driver of keratin mutation-based palmoplantar keratoderma
    Article Snippet: SF was obtained from LKT Laboratories Inc. Microarray analysis At the time of harvest, forepaws were degloved to isolate paw skin, and the nonvolar skin was removed with a razor blade. .. Total RNA isolated from paw skin, epidermis and dermis, of 2 month old Krt16 -null (2 males, 2 females) and WT (2 males, 2 females) littermates (see Biochemical and morphological analyses ) was subjected to microarray analysis by the Johns Hopkins Deep Sequencing Microarray Core using the Affymetrix Mouse Transcriptome Array 1.0 GeneChip. .. Affymetrix CEL files were extracted with the Partek Genomics Suite 6.6 platform.

    Microarray:

    Article Title: Altered keratinocyte differentiation is an early driver of keratin mutation-based palmoplantar keratoderma
    Article Snippet: SF was obtained from LKT Laboratories Inc. Microarray analysis At the time of harvest, forepaws were degloved to isolate paw skin, and the nonvolar skin was removed with a razor blade. .. Total RNA isolated from paw skin, epidermis and dermis, of 2 month old Krt16 -null (2 males, 2 females) and WT (2 males, 2 females) littermates (see Biochemical and morphological analyses ) was subjected to microarray analysis by the Johns Hopkins Deep Sequencing Microarray Core using the Affymetrix Mouse Transcriptome Array 1.0 GeneChip. .. Affymetrix CEL files were extracted with the Partek Genomics Suite 6.6 platform.

    Sequencing:

    Article Title: Altered keratinocyte differentiation is an early driver of keratin mutation-based palmoplantar keratoderma
    Article Snippet: SF was obtained from LKT Laboratories Inc. Microarray analysis At the time of harvest, forepaws were degloved to isolate paw skin, and the nonvolar skin was removed with a razor blade. .. Total RNA isolated from paw skin, epidermis and dermis, of 2 month old Krt16 -null (2 males, 2 females) and WT (2 males, 2 females) littermates (see Biochemical and morphological analyses ) was subjected to microarray analysis by the Johns Hopkins Deep Sequencing Microarray Core using the Affymetrix Mouse Transcriptome Array 1.0 GeneChip. .. Affymetrix CEL files were extracted with the Partek Genomics Suite 6.6 platform.



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    deep sequencing and microarray core facility  (Johns Hopkins HealthCare)
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    Johns Hopkins HealthCare deep sequencing and microarray core facility
    Deep Sequencing And Microarray Core Facility, supplied by Johns Hopkins HealthCare, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/deep+sequencing+microarray/deep+sequencing+and+microarray+core/pm39341835-495-13-6
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    deep sequencing and microarray core  (Johns Hopkins HealthCare)
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    Johns Hopkins HealthCare deep sequencing and microarray core
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    deep sequencing microarray  (Johns Hopkins HealthCare)
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    Analysis of global gene expression in Krt16-null footpad lesions and comparison to human PC cases. (A) Volcano plot depicting differentially expressed genes in Krt16-null paw skin lesions relative to WT controls. (B) Top 10 genes differentially regulated in Krt16-null paw skin from established paw lesions compared to WT littermate controls. (C) Validation of downregulated genes identified by <t>microarray</t> analysis by RT-qPCR in Krt16-null paw skin lesions. N = 4 mice/genotype. Error bars are SEM. *P < 0.05, **P < 0.01. (D) Overlap in the significantly changed genes that are upregulated between Krt16-null paw skin lesions and KRT16 human cases. (E) Overlap in the significantly changed genes that are downregulated between Krt16-null paw skin lesions and KRT16 human cases. (F) Overlap in the significantly changed genes that are upregulated between Krt16-null paw skin lesions and KRT6 human cases. (G) Overlap in the significantly changed genes that are downregulated between Krt16-null paw skin lesions and KRT6 human cases. Boxes for (D)–(G) list common genes between mouse and human data sets (listed in alphabetical order).
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    deep sequencing & microarray core facility  (Johns Hopkins HealthCare)
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    Analysis of global gene expression in Krt16-null footpad lesions and comparison to human PC cases. (A) Volcano plot depicting differentially expressed genes in Krt16-null paw skin lesions relative to WT controls. (B) Top 10 genes differentially regulated in Krt16-null paw skin from established paw lesions compared to WT littermate controls. (C) Validation of downregulated genes identified by <t>microarray</t> analysis by RT-qPCR in Krt16-null paw skin lesions. N = 4 mice/genotype. Error bars are SEM. *P < 0.05, **P < 0.01. (D) Overlap in the significantly changed genes that are upregulated between Krt16-null paw skin lesions and KRT16 human cases. (E) Overlap in the significantly changed genes that are downregulated between Krt16-null paw skin lesions and KRT16 human cases. (F) Overlap in the significantly changed genes that are upregulated between Krt16-null paw skin lesions and KRT6 human cases. (G) Overlap in the significantly changed genes that are downregulated between Krt16-null paw skin lesions and KRT6 human cases. Boxes for (D)–(G) list common genes between mouse and human data sets (listed in alphabetical order).
    Deep Sequencing & Microarray Core Facility, supplied by Johns Hopkins HealthCare, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    deep sequencing & microarray core  (Johns Hopkins HealthCare)
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    Johns Hopkins HealthCare deep sequencing & microarray core
    Analysis of global gene expression in Krt16-null footpad lesions and comparison to human PC cases. (A) Volcano plot depicting differentially expressed genes in Krt16-null paw skin lesions relative to WT controls. (B) Top 10 genes differentially regulated in Krt16-null paw skin from established paw lesions compared to WT littermate controls. (C) Validation of downregulated genes identified by <t>microarray</t> analysis by RT-qPCR in Krt16-null paw skin lesions. N = 4 mice/genotype. Error bars are SEM. *P < 0.05, **P < 0.01. (D) Overlap in the significantly changed genes that are upregulated between Krt16-null paw skin lesions and KRT16 human cases. (E) Overlap in the significantly changed genes that are downregulated between Krt16-null paw skin lesions and KRT16 human cases. (F) Overlap in the significantly changed genes that are upregulated between Krt16-null paw skin lesions and KRT6 human cases. (G) Overlap in the significantly changed genes that are downregulated between Krt16-null paw skin lesions and KRT6 human cases. Boxes for (D)–(G) list common genes between mouse and human data sets (listed in alphabetical order).
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    https://www.bioz.com/product/deep+sequencing+microarray/deep+sequencing+and+microarray+core/pm29893754-17-0-9
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    Image Search Results


    Analysis of global gene expression in Krt16-null footpad lesions and comparison to human PC cases. (A) Volcano plot depicting differentially expressed genes in Krt16-null paw skin lesions relative to WT controls. (B) Top 10 genes differentially regulated in Krt16-null paw skin from established paw lesions compared to WT littermate controls. (C) Validation of downregulated genes identified by microarray analysis by RT-qPCR in Krt16-null paw skin lesions. N = 4 mice/genotype. Error bars are SEM. *P < 0.05, **P < 0.01. (D) Overlap in the significantly changed genes that are upregulated between Krt16-null paw skin lesions and KRT16 human cases. (E) Overlap in the significantly changed genes that are downregulated between Krt16-null paw skin lesions and KRT16 human cases. (F) Overlap in the significantly changed genes that are upregulated between Krt16-null paw skin lesions and KRT6 human cases. (G) Overlap in the significantly changed genes that are downregulated between Krt16-null paw skin lesions and KRT6 human cases. Boxes for (D)–(G) list common genes between mouse and human data sets (listed in alphabetical order).

    Journal: Human Molecular Genetics

    Article Title: Altered keratinocyte differentiation is an early driver of keratin mutation-based palmoplantar keratoderma

    doi: 10.1093/hmg/ddz050

    Figure Lengend Snippet: Analysis of global gene expression in Krt16-null footpad lesions and comparison to human PC cases. (A) Volcano plot depicting differentially expressed genes in Krt16-null paw skin lesions relative to WT controls. (B) Top 10 genes differentially regulated in Krt16-null paw skin from established paw lesions compared to WT littermate controls. (C) Validation of downregulated genes identified by microarray analysis by RT-qPCR in Krt16-null paw skin lesions. N = 4 mice/genotype. Error bars are SEM. *P < 0.05, **P < 0.01. (D) Overlap in the significantly changed genes that are upregulated between Krt16-null paw skin lesions and KRT16 human cases. (E) Overlap in the significantly changed genes that are downregulated between Krt16-null paw skin lesions and KRT16 human cases. (F) Overlap in the significantly changed genes that are upregulated between Krt16-null paw skin lesions and KRT6 human cases. (G) Overlap in the significantly changed genes that are downregulated between Krt16-null paw skin lesions and KRT6 human cases. Boxes for (D)–(G) list common genes between mouse and human data sets (listed in alphabetical order).

    Article Snippet: Total RNA isolated from paw skin, epidermis and dermis, of 2 month old Krt16 -null (2 males, 2 females) and WT (2 males, 2 females) littermates (see Biochemical and morphological analyses ) was subjected to microarray analysis by the Johns Hopkins Deep Sequencing Microarray Core using the Affymetrix Mouse Transcriptome Array 1.0 GeneChip.

    Techniques: Gene Expression, Comparison, Biomarker Discovery, Microarray, Quantitative RT-PCR